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KMID : 0350519950480010187
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.187 ~ p.195
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Correlation between the Magnetic Resonance Findings of Hypothalamic- Pituitary Structure and Status of Growth Hormone Deficiency in Chidren with Idiopathic Growth Hormone Deficiency.
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Abstract
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We evaluated the magnetic resonance(MR) images of 26 children with idiopathic growth hormone deficiency(GHD) in an attempt to define more clearly the abnormalities of hypothalamohypophyseal axis, determine the frequency of these abnormalities and
determine whether a relationship exists between the MR findings and the patients clinical history and status of GHD.
All patients were divided into two groups by peak GH level after at least two GH provocation test : 16 cases of complete GHD(peak level<5 ng/ml) and 10 cases of partial GHD(peak level 5-10 ng/ml). In each group, the size of sella turcica and
anterior
lobe of pituitary, the location of posterior lobe of pituitary and the presence of pituitary stalk was evaluated on each film of T1-weighted MR findings eperformed in both the coronal and sagittal planes.
@ES The results were as follows :
@EN 1. The size of sella and anterior lobe of pituitary gland in patients with complete GHD were significantly smaller than those in partial GHD(P<0.01). Ectopic posterior lobe of pituitary in 5 cases (31.3%), undetectable or thin pituitary stalk
in 7
cases(43.8%) and empty sella in 5 cases(25.0%) of 16 complete GHD were seen.
2. The patients with complete GHD had abnormal perinatal events, especially breech delivery or birth asphyxia, in 68.8% of 16 total cases and these patients showed more frequent and prominent abnormalities of hypothalamic-pituitary structure
compared
with the patient of complete GHD without perinatal events and these all cases had other pituitary hormone deficiency.
3. All patients with partial GHD revealed no abnormalities of hypothalamic-pituitary structure and no history of perinatal insults and no other pituitary hormone deficiency.
Our results suggested that the abnormalities of the hypothalamic-pituitary structure by Mr image were common in children with idiopathic GHD and these abnormalities were related to severity of GHD and perinatal insults.
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KEYWORD
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